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Up to 300 milligrams (mg) of allopurinol can be taken at one time. You will need to discuss the benefits and risks of using Allopurinol  while you are pregnant. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite).

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